Lee Corso is most famous for his work on ESPN's College GameDay program, where he predicts the outcomes of the day's upcoming college football games. He plays the role of comic foil to co-hosts Chris Fowler and Kirk Herbstreit, as they cover the major college football games from August until January. Corso's catch phrase: "Not so fast, my friend!", usually directed at Kirk Herbstreitt, in disagreement with Herbstreit's predictions. Corso is also known for ending every show with his "Mascot Head Prediction," in which he will choose who he thinks will win the game at Gameday's site that week by donning the headpiece of the school's mascot.

Corso was born in Orlando, Florida and attended Florida State University on a football and baseball scholarship, where he roomed with future Hollywood star Burt Reynolds.

Upon graduating in 1959 with a degree in physical education, Corso became the quarterbacks coach at the University of Maryland under his former FSU coach Tommy Nugent. In 1969, he was given the head coaching position at the University of Louisville. After taking Louisville to its first-ever bowl game in 1972, he was hired by Indiana University. Corso's record was 41-68-2 over his ten years at Indiana before moving into an analyst position with ESPN. He usually travels from Florida for any appearance or speaking engagement.