During a 17-year baseball career, Cone pitched from 1986-2003 for six different teams. Cone pitched the sixteenth perfect game in baseball history. He was a member of five World Series championships (1992 with the Toronto Blue Jays and 1996, 1998, 1999 and 2000 with the New York Yankees). He has a career 8–3 postseason record over 21 postseason starts and a postseason ERA of 3.80. In 1994, with the Royals, Cone went 16-4 with a 2.94 ERA and was awarded the AL Cy Young Award.
He is the subject of the book A Pitcher's Story: Innings With David Cone by Roger Angell. His fans are known as "Cone-Heads."
In 2011, Cone became a color commentator for the Yankees on the YES Network.