Stan Humphries is a former NFL quarterback where he played for the Washington Redskins and San Diego Chargers. He played college football at Northeast Louisiana (now named the University of Louisiana at Monroe). He was selected by the Redskins in the 6th round of the 1988 NFL Draft.

In his third NFL season in 1990, Humphries made his first pro start in Phoenix against the Cardinals with regular starter Mark Rypien sidelined with an injury, Humphries passed for 1,015 yards and three touchdowns in seven games in 1990, he was also on the Redskins Super Bowl team of 1991. He was traded to the Chargers before the start of the 1992 season following the pre season injury to Charger QB John Friesz, the two teams ran the same offense, allowing Humphries to quickly make an impact. He passed for 3,356 yards, which ranked fifth in the league that year. He started for San Diego for six years, making 81 starts in 88 games while completing 1,431 of 2,516 passes for 17,191 yards and 89 touchdowns. San Diego was 47-29 in regular-season games and 3-3 in playoff contests he started from 1992-97. Humphries was known as a player that played with great determination despite injury. He played with a separated left shoulder in the 1992 AFC Wildcard Playoffs in which the Chargers defeated the Kansas City Chiefs 17-0 but lost to the Miami Dolphins 31-0 in the AFC Divisional Playoffs the following week.The Chargers would win 62 percent of the games he started over six years.

In 1994, he led the Chargers through an impressive series of victories through the NFL Playoffs that started with the Chargers defeating the Miami Dolphins (led by Hall of Fame quarterback Dan Marino) 22-21 in the divisional playoffs, and was followed by what would become one of pro football's all-time great upsets as the Chargers succeeded in holding off a last-minute rally by the Pittsburgh Steelers to win the AFC championship 17-13 at Pittsburgh's Three Rivers Stadium. The Chargers would then advance to Super Bowl XXIX for the first time in franchise history, losing to the San Francisco 49ers 49-26. Humphries' toughness took its toll. He was forced to leave the game after a series of concussions.

He was inducted into the San Diego Charger Hall of Fame in 2002.