Swin Cash was an All-American at the University of Connecticut (UConn). She won the NCAA Women's Division I Basketball Championship with the UConn Huskies in 2000 and 2002. She also helped lead UConn to an undefeated 39-0 season in 2002. Swin was a member of the inaugural class (2006) of inductees to the University of Connecticut women's basketball "Huskies of Honor" recognition program.

Cash was selected by the Detroit Shock in the 2002 WNBA Draft, second overall. After leading the Shock's resurgence in the second half of her rookie season, she then led the Detroit Shock to their first WNBA Championship title in 2003. She played in the 2003 WNBA All-Star Game and won the gold medal with the U.S. women's basketball team at the 2004 Olympic Games.

In the off-season, Cash has appeared as a studio analyst on ESPN's NBA Fastbreak and during the 2008 Beijing Olympic games, she alternated with Teresa Edwards in presenting in-game commentary for NBC's presentation of the women's basketball tournament from the network's New York broadcast studios. Swin appeared (as herself) in the movie Bring It On: All or Nothing.

Cash received the Dapper Dan Sportswoman of the Year award in April 2007. This is an award given to someone who shows excellence to the Pittsburgh area. She was also honored with Sidney Crosby and Dan Rooney. On February 19, 2008 Cash was traded to the Seattle Storm. Cash helped the Storm win their second championship in 2010. On January 2, 2012, in perhaps the WNBA's biggest blockbuster trade news thus far, Cash was traded, along with Le'Coe Willingham, to the Chicago Sky joining All- Star Sylvia Fowles.

Cash was one of 21 finalists for the U.S. Women’s Olympic Basketball Team Roster to compete in the 2012 London Olympics. Off the court, Cash has also founded the Pennsylvania based Cash for Kids charitable organization.