Lederer is known as "the Poker Professor" because of his demeanor, analytical style and long history of wins. He has made an instructional poker video called Secrets of No Limit Hold'em and he runs the Howard Lederer Poker Fantasy Camp. He also has co-hosted Poker Superstars and Learn from the Pros for the Fox Broadcasting Company.
He has won several World Series of Poker bracelets and World Poker Tour titles. In 2008, he won A$1.25 million by winning the $100,000 No Limit Holdem Challenge, billed at the time as the world's most expensive tournament buy-in, at the Aussie Millions.
His total live tournament winnings have exceeded $6,000,000.