Helton debuted in Major League Baseball in 1997 with the Colorado Rockies. As of the end of the 2011 season, among all active players, Helton was first in on-base percentage (.421), tied for second in doubles (554), third in intentional walks (183), and eighth in slugging percentage (.550).
Helton has held the Colorado Rockies club records for hits (2,407), home runs (354), doubles (566), walks (1,283), runs scored (1,355), RBIs (1,340), games played (2,105), total bases (4,107) and other categories. Helton hit his 2,000th career hit against the Atlanta Braves on May 19, 2009.
In 2000, he won the NL batting champion. Helton also won four straight Silver Slugger awards from 2000-2003.