Andre Reed played wide receiver in the NFL for 16 seasons, 15 with the Buffalo Bills (1985-1999) and one with the Washington Redskins (2000). He is widely considered one of the best wide receivers to ever play the game.

Reed ranks highly in many career NFL receiving categories. He retired fourth in receptions with 951 (behind only Jerry Rice, Cris Carter and Tim Brown), sixth in receiving yards with 13,198, and tenth in touchdowns receptions with 87. With the Bills, Reed played in four consecutive Super Bowls (1991-1994) and was selected to the Pro Bowl seven times in a row (1988-1994). Reed set career highs with 90 receptions in 1994, 10 touchdowns in 1991, and 1,312 receiving yards in 1989.

In addition to the important role he played in taking the Bills to four Super Bowls, Reed is remembered particularly for his contributions to the Bills' January 3, 1993 playoff victory over the Houston Oilers, a game that has come to be known simply as "The Comeback". In the game, which Houston led 35-3 at half time, Reed caught three touchdowns in the second half to lead the Bills to the largest comeback in the history of the NFL. The game is considered one of the most extraordinary comebacks in all of American sports.