Amy has six career Olympic gold medals. Four of these gold medals came in the 1996 Summer Olympics, making her the first American woman to accomplish such a feat. She won gold in the 50 meter free, 100 meter butterfly, 4 x 100 meter freestyle relay, and the 4 x 100 meter medley relay. She also placed fourth in the 100 meter free.

In the 2000 Olympic games, Amy won two more gold medals. She has won several World titles and set many American and World records. 

Since retiring from swimming, she has had several speaking engagments all across the country, worked as a sideline reporter for the Seattle Seahawks and Denver Broncos, and been heavily involved with the Make-A-Wish Foundation. She was inducted into the Interanation Swimming Hall of Fame as the first woman American swimmer in 2007 and then in 2008, she was inducted into the Olympic Hall of Fame. From 2010-2011, Amy worked as a morning drive time host of 98.7 The Peak in Phoenix.